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PKM-zeta inhibitormostly known as ZIP (Zeta Interacting Protein), is an experimental drug tested with Post-Traumatic Stress Disorder victims. When the drug is used sparingly, it can erase selective memories.

On the Show

Season 1

Dr. Borden explained that Jane's body was flooded with the drug, causing her an induced state of permanent amnesia, reason of why she can't remember who she is or where she came from.

Oscar tries to use the drug on Jane once again after stating that Marcos was too cautious with the dosis the first time, which made Jane remember certain things from her past.

Season 2

After Roman was shot and taken by Jane to a warehouse in order to patch his wound, she injects him with ZIP so he could start all over again and become a new person just the way she did after her entire memory was wiped.

ZIP Poisoning

According to Robert Borden, when ZIP is used sparingly, it can erase selective memories from a subject; however, high dozes and prolonged exposure to it will result in death.


  • Dizziness
  • Nausea
  • Fatigue
  • Massive memory lapses
  • Memory relapses
  • Brain aneurysms
  • Hallucinations
  • Death


The following is a list of episodes in which ZIP is mentioned and showed.

Ep. Image Episode Title Context
ZIP 101.png
Woe Has Joined Dr. Robert Borden introduces ZIP to Kurt Weller and Bethany Mayfair while explaining that Jane Doe’s system was flooded with the drug and caused a permanent state of amnesia. 
ZIP 112.png
Scientists Hollow Fortune The drug is given to Charlie in order to wipe his memory again.
ZIP 123.png
Why Await Life's End Worried about his personal involvement with Jane and after making the mistake of killing Mayfair in front of her, Oscar decided to use ZIP on her again to keep his cover safe.
ZIP 209.png
Why Let Cooler Pasture Deform On a desperate attempt to save her brother from his past and Shepherd, Jane injects Roman with ZIP to wipe his memory and give him a new chance to start again.